Treatment Marble Bone Disease

Bone marrow transplant is the only chance for survival in patients with osteopetrosis congenita.

Treatment marble bone disease.

Marble this disease named for two reasons. Osteopetrosis literally stone bone also known as marble bone disease or albers schönberg disease is an extremely rare inherited disorder whereby the bones harden becoming denser in contrast to more prevalent conditions like osteoporosis in which the bones become less dense and more brittle or osteomalacia in which the bones soften. This means that the bone tissue is substantially sealed. This condition in turn leads to bones getting dissolved and ultimately break.

The most informative tool in determining the presence of marble disease is an x ray. Marble bone disease when there is a failure in bone resorption. The marrow cavities become filled with compact bone. Osteogenesis imperfecta or brittle bone disease is a group of hereditary connective tissue disorders characterized by unusual bone fragility and tendency to fracture.

Marble bone disease description causes and risk factors. The musculoskeletal system consists of the body s bones muscles tendons ligaments joints cartilage. Because increased bone mass crowds the bone marrow resulting in a reduced amount of marrow. The disease progresses as long as bone growth continues.

Find diagnosis treatment and prevention information on more than 20 different muscle and bone diseases and conditions affecting the musculoskeletal system. In healthy individuals bones are constantly being broken down resorption by cells called osteoclasts and new bone material is constantly being formed by cells called osteoblasts. Osteopetrosis or marble bone disease this is an extremely rare genetic disorder of the bones in which the bones get harder and denser. Traditionally the disease has been recognized in two forms.

Osteopetrosis marble bone disease osteopetrosis tarda albers schonberg disease. Osteogenesis imperfecta congenita which is apparent at birth and osteogenesis imperfecta tarda which manifests itself usually in early childhood with milder. Symptoms and severity can vary greatly ranging from neonatal onset with life threatening complications such as bone marrow failure to the incidental finding of osteopetrosis on x ray depending on severity and age of onset features may include fractures. Introduction osteopetrosis is a disorder characterized by defective or absent osteoclasts the cells that resorb bone was first described in 1904 by heinrich albers schenberg.

Osteopetrosis refers to a group of rare inherited skeletal disorders characterized by increased bone density and abnormal bone growth. The mass of bone increases but the new bone material.